KMID : 1377020130100060347
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Tissue Engineering and Regenerative Medicine 2013 Volume.10 No. 6 p.347 ~ p.352
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The effect of microgrooves on osseointegration of titanium surfaces in rabbit calvaria
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Song Eun-young
Yoon Ji-young Yoon Jung-ho Lee Myung-Hyun Lee Suk-Won Oh Nam-Sik
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Abstract
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The purpose of this study was to evaluate bone formation ability and bone-implant adhesion over time when microgrooves are present on the surface of cylindrical titanium implants. Eight New Zealand White rabbits with a weight of approximately 3.5 kg were used. Cylindrical titanium implants with a smooth surface (NE0), acidetched rough surface (E0), and microgroove surface (NE60/10) were placed in each rabbit¡¯s skull, with one implant of each type placed in each skull. Experimental animals were sacrificed after 2 and 4 weeks, and tissue specimens were processed for histomorphometric analysis of bone formation by measuring bone-implant contact (BIC) and the degree of differentiation. The bone-implant contact ratio at 2 and 4 weeks was 15.9% and 29.6% (NE0), 15.6% and 34.5% (E0), and 15.3% and 52.7% (NE60/10), respectively. Good bone regeneration was observed in all experimental groups; at 4 weeks, in particular, the NE60/10 group showed high bone contact relative to the control group (p < 0.05), and other groups showed stable and mature bone. On the basis of the observed increase in bone-implant adhesion at the titanium surface, microgrooves with a width of 60 ¥ìm and depth of 10 ¥ìm are considered to promote implant osseointegration.
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KEYWORD
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titanium implants, acid-etching, micro-groove, osseointegration, bone-implant contact ratio
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